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Sterol feedback regulation is characteristic of all genes involved in cholesterol biosynthesis and homeostasis, whereas cAMP-dependent regulation is unique, suggesting that CYP51A1 may play a tissue-specific role distinct from cholesterol biosynthesis

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But they are also dose-dependent and temporary

Thus, disrupting multiple key steps in the lipid catabolism pathway had little impact on fasting-induced lifespan extension, indicating that the breakdown and utilization of lipids is not needed to confer the longevity benefits associated with fasting