Although lowering of insulin levels with diet or drugs such as metformin and diazoxide seems generally beneficial, some practitioners also utilize strategic elevations of insulin levels in combination with chemotherapeutic drugs
The basic leucine zipper ATF-like transcription factor (Batf), a member of the activator protein-1(AP-1) transcription factor family, not only inhibits IL-2 expression but also indirectly inhibits the assembly of the STAT5-E-twenty-six 1 (Ets1)-Runx1 complex to induce and maintain the development of Th17 cells [31]
The increased expression of lipogenic enzymes, such as acetyl-CoA carboxylase, fatty acid synthase, and ATP-citrate lyase, represents a nearly-universal phenotypic alteration in most tumors 29,294,309
10.4314/ahs.v15i1.18 36 MattioliA
Simple rule: start conservative, re-test in a few weeks, and adjust to your objective labs + how you feel