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Additionally, elevated glucose levels lowered lysine methyltransferase 8 (SETD8) expression and increased myeloid zinc finger 1 (MZF1) expression

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Moreover, BHBA triggered an increase of intracellular Ca 2+ via L-type VSCCs, which in turn activated the Ca 2+ /CaMKII/p-CREB signaling pathway and subsequently induced BDNF expression in primary hippocampal neurons

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Nausea scoring above 5 out of 10 consistently for more than 10 days at a given dose