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Am J Physiol Renal Physiol 314:F702f14 Kwon MY, Park E, Lee SJ, Chung SW (2015) Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

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The release rate is tunable by varying the substitution on the phenyl ring, with electron-donating groups accelerating the release at acidic pH

Esophageal adenocarcinoma in Barretts esophagus after endoscopic ablative therapy: a meta- analysis and systematic review

This process is accompanied by the ETC breakdown with the failure to produce the necessary amount of ATP, uncompensated production of ROS and RNS, and breakdown of various molecules, which leads to the loss of mitochondrial and cell integrity, and activation of programmed cell death and necrosis