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HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice

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For the 9 mg target, doses increased in steps at 2 mg, 4 mg, and 6 mg, with increases every four weeks until reaching 9 mg

We leveraged whole-genome, whole-exome and transcriptome sequencing (Methods) to detect genomic alterations including mutations, copy-number alterations, structural variants (SVs) and gene fusions (Fig

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