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The NMNAT1 and NMNAT3 transgenic mouse strains used here were as previously described (Yahata et al, 2009), and the colony was maintained through breeding heterozygous males with wild-type females, with a subsequent Mendelian ratio of offspring to be used for experiments of 50% heterozygous transgenics, and 50% wild-type littermate controls

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In a healthy individual, the body's antioxidant reservesled by glutathionequickly sweep in to neutralize these free radicals once the infection clears

Yano H, Oyanagi E, Kato Y, Samejima Y, Sasaki J, Utsumi K

402,403 In experimental models of depression, which are mainly based on exposure to unpredictable or social stress, numbers of GFAP-positive astrocytes, as well as GFAP levels in cortex and hippocampus, are significantly reduced