Curcumin can directly neutralize ROS and reactive nitrogen species, reducing oxidative damage to lipids, proteins, and DNA in dopaminergic cells (70)
Well start with the most obvious one
oestradiol (E2) bind ER or ER in mammary epithelial cells, followed by receptor dimerisation, nuclear translocation and direct transcriptional regulation of EREs in promoter regions on target genes that regulate cell proliferation cyclin D1, c-Myc -, survival Bcl-2 or survivin -, angiogenesis VEGF -, EMT Snail, Twist -, metastasis MMPs (185), as non-genomic oestrogen signalling via membrane-localized ER and G proteincoupled oestrogen receptor (GPER) leads to rapid stimulation of PI3K/Akt, MAPK/ERK and Src pathways interacting further impetus to mitogenic and anti-apoptotic effects
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinsons and Alzheimers disease brains
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