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The nucleocytoplasmic reductive shift during fasting is likely beneficial, as the [NAD + ] levels increase to activate sirtuins and the [NADH] levels increase to an even greater extent to activate the malate-aspartate shuttle (MAS) to potentially reduce the mitochondrial matrix [NAD + ]/[NADH], which may also play a role in neuroprotection and delayed aging
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Interestingly, the reduction of NRF2 levels has been associated with increased production of A (Rojo et al., 2017)
2018;103(12):1155-1162.doi:10.1136/archdischild-2017-314181 Besag FMC, Vasey MJ, Lao KSJ, WongICK
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