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The maximal therapeutic dose recommended by the FDA is 4 g/day

Stewart CA, Gay CM, Xi Y, Sivajothi S, Sivakamasundari V, Fujimoto J, Bolisetty M, Hartsfield PM, Balasubramaniyan V, Chalishazar MD, Moran C, Kalhor N, Stewart J, Tran H, Swisher SG , Roth JA, Zhang J, de Groot J, Glisson B, Oliver TG, Heymach JV, Wistuba I, Robson P, Wang J, Byers LA

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The genetic or pharmacological restoration of GPX4 suppresses neutrophil ferroptosis and abrogates downstream autoimmunity, underscoring GPX4 as a checkpoint that constrains iron-driven inflammation (206, 217)