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Additionally, it plays a key role in signaling tissue remodeling, which removes damaged or scarred tissue and generates new, healthy tissue
Deregulated activation of c-Met contributes to a few aspects of tumor progression, such as inducing neoplastic cells to disaggregate from the tumor mass, eroding basement membranes, infiltrating stromal matrices, and finally colonizing new tissues to form metastases ( Onset Chronic liver diseases such as cirrhosis and hepatitis B or C are triggers of HCC ( N -nitrosodiethylamine-induced HCC ( As mentioned above, c-Met is aberrantly activated by gene amplification, overexpression, mutation, binding to other ligands, autocrine signaling or abnormally high HGF levels in cancer
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We will base our conclusions on this understanding about these proteins and their potential role in barrier deregulation and/or repair and regeneration properties