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Subcutaneous injection was chosen as 5A-1MQ specifically has poor oral bioavailability in mice, a phenomenon that does not occur in rats 26

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ACS Appl Mater Interfaces 13(8):95009519 Li L et al (2021) Nucleic acid aptamers for molecular diagnostics and therapeutics: advances and perspectives

The higher potency of Receptor Grade IGF-1 LR3 towards the IGF-1 receptors may make it the preferred molecule for studies involving cell division