Current research has significantly explored the bidirectional relationship between dysregulated brain metabolism and sleep impairments in influencing aging as well as age-associated neurocognitive deficits, and suggests that alterations in any one of them exacerbate the other, leading to accelerated aging and neurodegeneration ( vice versa , since impaired glucose utilization, lipid metabolism as well as oxidative stress in the mitochondria, are altered as we age and conversely, exacerbated ROS and a decline in bioenergetics in neuroglial cells, aggravates aging and cognition (Srivastava, 2017)
Tryptophan metabolism and gut-brain homeostasis
Use vitamin C in the morning, peptides at night, or choose a formula designed to combine them
Therefore, the antioxidant-like and antiapoptotic function attributed to Bcl-2 could, at least in part, depend on its potential to regulate the mGSH transport and status
Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S