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The ice crystal formation physically damages the peptide structure, and this damage does not reverse when the solution thaws

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11(5): 206-9 3Enseleit F, Sudano I, Priat D, Winnik S, Wolfrum M, Flammer AJ, Frhlich GM, Kaiser P, Hirt A, Haile SR, Krasniqi N, Matter CM, Uhlenhut K, Hgger P, Neidhart M, Lscher TF, Ruschitzka F, Noll G