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The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity

C., Suhandi, C., Afidika, J., Ghaliya, S., Elamin, K

Deficiency leads to methylmalonic acid accumulation, which can cause neurological damage over time

In the elderly, hypothyroidism is associated with accelerated cognitive decline and an increased risk of Alzheimer's disease, raising the possibility that impaired thyroid signaling may act as a modifiable risk factor for dementia (83)

Cleavage of the -glutamyl bond of the substrate, the first step in the reaction, results in the formation of an acyl bond between the glutamate and the catalytic threonine of the enzyme with the release of all but the glutamate portion of the substrate