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BS was responsible for the conception and design of this review article

Hormonal fluctuations, particularly during pregnancy or when taking oral contraceptives, can trigger melasma, a type of hyperpigmentation characterized by symmetrical brown patches typically appearing on the face

43 Paracellular diapedesis represents the predominant pathway for leukocyte extravasation from the vasculature

By blocking NF-kB activation in intestinal tissue, KPV reduces the production and release of pro-inflammatory cytokines that would otherwise enter systemic circulation and cross into the brain