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Cortisol dysregulation also becomes more pronounced as estrogen withdrawal activates the HPA axis, producing the elevated baseline stress-hormone output that drives the "tired but wired" pattern common in midlife women

Available evidence covering the pathophysiology of both maternal and fetal manifestations, and potential new areas of interest such as microbiota and the environment, have been reviewed, as well as available biomarkers that can be used particularly with regard to genetics, multiomics and the possible use of machine learning algorithms to predict intrahepatic cholestasis of pregnancy

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Faster collagen synthesis

It may help manage inflammation, blood sugar, cholesterol, and blood pressure, among other benefits