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There are studies that reported significant association to T2DM for both null genotypes of GST [19], [20] and others that verified no association between GSTT1 and GSTM1 polymorphisms and T2DM [18], [21]

10.1186/s40425-017-0308-4 265 SteinE

Biological systems tend toward homeostasis, and prolonged interference with any single pathway component may trigger adaptive responses

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Likewise, an operational taxonomic unit (OTU3) within Bacteroides sharing 99.2% sequence similarity with Bacteroides acidifaciens , a species inversely correlated with obesitywas markedly diminished in PCOS-like mouse models (121)