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Contact your GP immediately, call NHS 111, or attend A&E if you develop: Irregular heartbeat or palpitations that persist Chest pain or pressure Severe breathlessness Significant leg swelling These symptoms require assessment to determine their cause, which may or may not be related to your B12 treatment

This effect is believed to be due to IGF-1 suppression of insulin secretion, which leads to augmented lipolysis in adipose tissue and promotion of FFA use by muscle

Zenobi PD, Jaeggi-Groisman SE, Riesen WF, Rder ME, Froesch ER

ISBN 0-521-82873-2

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