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During intrauterine hypoxia, the fetal circulation suffers marked adaptations in the fetal cardiac output to maintain oxygen and nutrient delivery to vital organs, known as the brain-sparing phenotype . This is a well-characterized response

by Rayva Khanna, MD

The spine formation was inhibited in the case when the GLUT 4 -mediated glucose uptake was blocked

The enzyme glutathione reductase (GR) , utilizing the coenzyme NADPH, steps in to break the disulfide bond, recycling GSSG back into the active, reduced GSH state