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A significant advantage of DSIP is that it does not induce artificial sleep but supports the natural processes necessary for restorative sleep

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ROS induce several other biological processes, including a transient increase in intracellular Ca 2+ concentration, phosphorylation of specific proteins, activation of some other transcription factors, modulation of eicosanoid metabolism and stimulation of cell growth [160]

The combined therapy effect involving both mucosal and sphincter function may be essential