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Mitochondrial biogenesis is only advantageous if mitochondria are functional We examined mitochondrial staining by TOM20 immunohistochemistry in HCT116 xenografts and AKP orthotopic tumours treated with 5FU and/or metformin

Citations [1] McCoy AT, Benoist CC, Wright JW, et al

Dysregulated iron homeostasis constitutes the fundamental basis for ferroptosis initiation ( 4.1 Molecular pathways governing ferroptosis cell death Iron is a critical driver of lipid peroxidation and subsequent ferroptosis within cellular environments ( Diminished activity of the cystine/glutamate antiporter (system Xc-) serves as the initial trigger for ferroptosis ( Ferroptosis substrates primarily include polyunsaturated fatty acids (PUFAs, characterized by their abundance of double bonds), free polyunsaturated fatty acids such as oxidized arachidonic acid, and adrenal hormones