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Long-chain fatty acids enhance Th17 cell differentiation, whereas short-chain fatty acids derived from a fiber-rich diet expand Treg cells and reduce IL-17 production (315)

Surprisingly, compared with the CM from the vector adipocytes, CM from the CPT2KD adipocytes remarkably upregulated the mRNA expression of pro-inflammatory macrophage markers in BMDMs, whereas CM from the SIRT3OE-CPT2KD adipocytes partially reversed these changes (Fig

This can happen due to low levels of intrinsic factors in the digestive system, digestive conditions, or following a plant-based diet

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