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References state that the dysbiosis is likely to be responsible for early stage PD GI-related problems, including constipation, with a notable increase in bacterial families that include Lactobacillaceae, Verrucomicrobiaceae, Bradyrhizobiaceae, Bifidobacterium , and Akkermansia (Hashish and Salama, 2023)

And somehow, it touches collagen production, wound healing, antioxidant activity, and the expression of thousands of genes at the same time

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With sterile water, that window shrinks dramatically, often to just a few days, before the risk of bacterial contamination renders your sample unusable