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Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma
Thyroid function tests should be monitored in patients receiving thyroid hormone replacement, and the timing of levothyroxine administration relative to semaglutide injection may need to be optimized to ensure consistent absorption
Subjects were advised no longer to take any vitamin B-complex, folate, and different dietary supplements in the course of the study and to inform researchers if there was a change in the type or dose of medication used
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