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PMCID: PMC6158718 )

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Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase

In controlled studies, TB500 promotes restoration of tissue integrity post-injury through enhanced cell motility and structural protein expression

Abstract For over 100 years, clinicians and scientists have been unravelling the consequences of the A to T substitution in the -globin gene that produces haemoglobin S, which leads to the systemic manifestations of sickle cell disease (SCD), including vaso-occlusion, anaemia, haemolysis, organ injury and pain