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First, FOXO4 localizes predominantly in the cytoplasm of normal Leydig cells, as shown by both our in vitro and in vivo findings, while it is within the nucleus that FOXO4-DRI interferes with the FOXO4-p53 interaction [24]

Nature 613 , 383390 (2023)

The final 200-ns segment of the 500-ns MD simulation was used for RMSF analysis and binding free energy calculations

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