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Similarly, mutations in the ATP13A2 gene associated with PD result in widespread lysosomal impairment, characterized by membrane instability, impaired acidification, reduced processing of lysosomal enzymes, and diminished degradation of substrates and autophagosomes [118]

pCW-Cas9-Blast expressing 786-O and HT-1080 cells were used to generate FSP1-KO cells by lentiviral infection with particles containing the desired sgRNA expressing pKLV-U6gRNA(sgRNA)-PGKpuro2ABFP

A mriatvis (Sylibum marianum) egszsgvd, s az obstruktv lgti megbetegedsekben kedvez N-acetilcisztein (NAC) hatst szintn glutationtermelst fokoz kpessgeiknek tulajdontjk [i]

J Natl Compr Canc Netw 6(9):818-49, 2008

Di Giacomo C, Malfa GA, Tomasello B, Bianchi S, Acquaviva R