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In RA model, some natural medicines (such as resveratrol, baicalin and -mangiferin) antagonize the transcriptional activity of NF-B by up-regulating the expression of SIRT1, thereby inhibiting the expression of a variety of inflammatory cytokines (such as TNF, IL-6 and IL-1), and inhibiting the proliferation, invasion and migration of FLSs, which has a positive effect on RA

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Interaction with the microbial community Compared with flavonols and flavones, intact flavanones have a higher bioavailability in the human gut, due to the fact that a lower percentage is converted by intestinal microbiota (Reference Marn, Migulez and Villar66)

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