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Although these findings were observed in non-CRC models, they are highly relevant to CRC, where hypoxia-driven chemoresistance remains a significant challenge (141)

Notably, liraglutide, a GLP-1 receptor agonist, has been shown to exhibit neuroprotective effects and mitigate cognitive decline in both experimental and observational studies (131)

Generally, a simple skin pinch procedure or microfat transfer can be performed under local anesthesia

Cognitive impairment represents a major global public health challenge, encompassing a clinical spectrum from mild cognitive impairment to severe dementia

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