One of the most universally debilitating aspects of complex chronic illness is severe neurocognitive impairment, commonly and somewhat dismissively referred to as brain fog
However, it is worth investigating whether AMPK has positive impacts on DKD by inhibiting ferroptosis
This review aims to outline the relevant mechanisms of ferroptosis, its implications in the bone microenvironment, and the mechanisms of action and therapeutic perspectives of ferroptosis in common bone and joint diseases, with the goal of informing future clinical research and treatment strategies targeting ferroptosis under these conditions
15 EichlerK.BourgisF.BuchetA.KleberH
A separate meta-analysis that pooled results of trials in older adults with mild cognitive impairment found B-vitamin supplementation (6 to 24 months, depending on the trial) had no benefits on various cognitive parameters, including executive function, information processing speed, and episodic memory (90)