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As one of the most important dopamine-replacement therapies for PD, L-DOPA is commonly given with carbidopa to improve bioavailability and avoid early conversion into dopamine before penetration into the brain (Gandhi and Saadabadi, 2025)
Type of study: Number of citations: 1 Year: 2025 Authors: Kehan Chen, Hui Yang, Guo Xu, Yunhan Hu, Xue Tian, Song Qin, Tianyue Jiang Journal: RSC medicinal chemistry Journal ranking: Q1 Key takeaways: The Cur-CNEs/Gel, an oligopeptide hydrogel encapsulating curcumin-loaded nanoemulsions, effectively enhances skin penetration and alleviates psoriasis symptoms in mice
Their beneficial mechanisms can include the attenuation of neuroinflammation [e.g., valproate via histone deacetylase (HDAC) inhibition in microglia, downregulating interleukin-1 beta (IL-1) and inducible nitric oxide synthase (iNOS)] or the mitigation of glutamatergic excitotoxicity coupled with enhancement of neurotrophic factor expression (e.g., lamotrigine), thereby conferring antidepressant-like potential (Mula and Sander, 2007
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
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