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Its role in cellular differentiation was disputed (Walsh and Bestor, 1999) and the current model is that, at least, repression of inactive X chromosomes and imprinted genes (silencing of parasitic sequence elements is still questionable) depends on heritable DNA methylation (Suzuki and Bird, 2008)

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10.1007/978-3-319-47754-1_10 168 RomoliniG.GambucciM.RicciarelliD.TarpaniL.ZampiniG.LatteriniL