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Its a problem that should never happen

Drugs (beta blockers, calcium channel blockers, and others) can treat really bothersome arrhythmias, but these drugs do cause side effects in some people

J Nutr Gerontol Geriatr (2012) 31:17689

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VDR -KD caused a simultaneous decrease in VD metabolism genes CYP27A1 , VDBP , and VDR , while upregulation of genes by VD+LC was abolished in VDR -KD hepatocytes (Supplementary Fig