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KD appears well positioned to intervene in this process, overlapping with broader microbiota-targeted strategiesincluding probiotics, synbiotics, FMT, and antibioticsthat are increasingly regarded as potential disease-modifying interventions in PD [129, 177]

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The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235