Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism
The first is Huppke-Brendel Syndrome, a severe neurodevelopmental disorder characterized by severe intellectual disability, motor deficits, and progressive neurodegeneration
doi: 10.1016/j.cell.2024.01.030 19 ConradMPrattDA
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This research was funded by the Hunan Provincial Natural Science FoundationMedical and Health Joint Fund, grant number 2024JJ9466