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Despite the thermodynamically highly favorable reverse reaction, PfGrx C88S (S 2 ) reacted very slowly with roGFP2 WT (SH) 2 most likely due to the instability and high energy of the Grx(SSR) intermediate

Parkinson's disease is characterized by a reduction in dopamine levels due to the loss of dopaminergic neurons in the substantia nigra, resulting in an imbalance between the direct and indirect pathways in the striatum