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As the years go by, that conductor starts to slow down, and the orchestra isn't quite as coordinated

[DOI] [PMC free article] [PubMed] [Google Scholar] 166.Prentice KJ, Saksi J, Hotamisligil GS

Since there are obvious differences between rodent and human physiology, it cannot be ignored that this may have a significant impact on the efficacy and safety of (any) novel agents

Stroke with transfusions changing to hydroxyurea (SWiTCH): a phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload

Over time, oxidative stress may contribute to various health concerns if left unchecked