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22(1):5374 The somatomedin hypothesis and insulin-like growth factor signaling in endocrine regulation Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, Le Roith D., Journal of Clinical Investigation , 2001

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355,356,357 According to most related studies, osteoclasts and osteoblasts are indispensable for bone remodeling, and bone resorption and bone formation are mediated by osteoclasts and osteoblasts, respectively

Published research describes upregulation of collagen I, collagen III, and elastin expression in fibroblast culture models