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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

Intl J Radiation Oncol/Biol/Physics 81(2):S134(#270), 2011

Riboflavin Status Modifies the Effects of Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase Reductase (MTRR) Polymorphisms on Homocysteine. Genes & Nutrition, vol

In the liver, it offers antioxidant support for liver tissue protection and promotes p450 phase II conjugation pathways to support detoxification

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