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The rise in extracellular adenosine levels acts as a potent antiinflammatory mediator central to methotrexates therapeutic effect, as illustrated in Figure 9

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Possible mild side effects include: Temporary nausea Mild headache Slight discomfort at injection site Avoid treatment if: Pregnant or breastfeeding Severe liver/kidney conditions Known allergies to components A proper consultation ensures safety and suitability

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