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doi: 10.1016/j.tox.2005.08.006 35 ChmelarRBuchananGNeedEFTilleyWGreenbergNM

I think we should talk. Over the following weeks, Sarah and Alex never stopped texting

The Collateral Damage: Allopregnanolone Allopregnanolone (ALLO) is synthesized in the brain from progesterone via a two-step pathway: Progesterone 5-dihydroprogesterone (via 5-alpha reductase) 5-DHP Allopregnanolone (via 3-HSD) Because 5-AR is the rate-limiting step, inhibiting it blocks ALLO productioneven when progesterone levels are adequate

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