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Another rat study found that acute restraint stress can upregulate TLR4 gene expression in the frontal cortex by inducing gut microbiota translocation, while intervention with antibiotics or the TLR4 specific inhibitor TAK-242 effectively suppresses this process and reduces the accumulation of inflammatory and oxidative/nitrosative mediators (163)

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Ghim M, Pang KT, Arshad M, Wang X, Weinberg PD (2018) A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator