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doi: 10.1016/S0046-8177(75)80040-2 173 PrinzM.HuberG.MacphersonA

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They stimulate the production of glycosaminoglycans , such as hyaluronic acid, which helps retain moisture and supports tissue hydration

Notable candidates in Phase II/III trials include arhalofenate (MBX102), AC201, the RDEA group (including lesinurad), tranilast, and ulodesine (BCX4208)

In laboratory settings it has been studied alongside NAD+ pathway components to assess downstream effects on mitochondrial function