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Animal toxicology studies lasting up to 9 months (in non-human primates) found no significant organ toxicity, genotoxicity, or reproductive toxicity

Some research protocols have explored doses up to 4.5 mg weekly, which showed slightly greater efficacy in the phase 2 dose-finding trial but also increased side effect burden

Benzodiazepines directly bind GABA receptors, producing sedation, amnesia, physical dependence, and withdrawal risk

KLOW dosage in research contexts is determined by the investigator's experimental design and the target concentration for each component

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