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Differential aetiologies of hypertension arise from complex interplays between genetic and environmental variables that modify biological pathways and lead to the disease ( 6.4

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262 In addition, in solid organ transplant recipients (SOTr), low DKK-1 and increased secreted frizzled related protein-3 levels causing dysregulation of Wnt signalling were closely associated with cytomegalovirus (CMV) infection