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Eur J Pharmacol 932:175208

Representative of 23 experiments (n = 3, two-sided unpaired t-test)

The material is supplied strictly for research use only and is not intended for human or veterinary administration, diagnostic use, therapeutic use, or consumer application

This characteristic allows exploratory evaluation of oral administration, although current data indicate that oral bioavailability is presumed lower than parenteral routes

349 Meanwhile, RA patients typically have lower antioxidants, such as GSH and GSH peroxidase, and treatment with methotrexate significantly changes oxidative stress indicators in RA patients