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Once digested, the amino acids become available for general use in the body, and whether they are preferentially routed to a healing knee is more complex than the marketing implies

A study that looked at 0.5-1mg/kg/day leucovorin in patients with cerebral folate deficiency (and related neurological symptoms) found that 90% of those supplemented achieved normal 5-methyltetrahydrofolate cerebral spinal fluid concentrations

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Acute injuries typically respond faster than chronic degenerative conditions

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