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Furthermore, T3-treated mice demonstrated diminished blood-brain barrier breakdown, evidenced by less cerebral edema, Evans Blue extravasation and aquaporin-4 expression, as well as less inflammation, thrombosis and apoptosis

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Additionally, a Phase 2 pilot trial that involved the use of the anti-herpetic drug acyclovir was established to be safe, feasible and tolerable for early AD, with a slight improvement in the mini mental state examination (MMSE) scores (Weidung et al., 2022)