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As far back as two thousand years ago, the ancient Greeks had a center for studying the effects of different colored lights on the body

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10.2147/CIA.S84940 107 HanS

Furthermore, activity of critical neurotransmitter synthesis enzymes such as dopamine beta hydroxylase have been long known to be reduced in AD (Cross et al., 1981), which are also dependent on copper for its catalytic activity and would likewise be compromised by copper deficiency (Vendelboe et al., 2016)