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Meanwhile, the route of Se delivery, bolus or continuous administration, and the patient selection are different between studies and may influence the observed effects of supplementation

The disease is characterized by: *Chronic lymphocytic infiltration of the thyroid gland *Elevated TPO antibodies (TPOAb) - present in over 90% of cases *Elevated thyroglobulin antibodies (TgAb) - present in 5080% of cases *Progressive thyroid fibrosis and loss of function *Eventual hypothyroidism requiring lifelong levothyroxine replacement The Oxidative Stress Signature of Hashimoto's The Antioxidants review (2021) confirmed that patients with Hashimoto's thyroiditis show a consistent pattern of oxidative stress markers: elevated malondialdehyde (MDA - a lipid peroxidation marker), reduced superoxide dismutase (SOD) activity, and critically, significantly decreased glutathione levels compared to healthy controls

The effect was investigated at daily intervals until the end of the fifth day after ligation